Computer-Assisted Cognitive Remediation (CACR) interventions are reliable and efficacious to improve the cognitive deficit in people with a diagnosis of schizophrenia (PSZ). Aim of this study was to investigate the illness duration effect on CACR efficacy. We divided a sample of 32 PSZ in those with a Short Duration of Disease (SDD; n = 12) and those with a Long Duration of Disease (LDD; n = 20). In the whole sample of 32 PSZ, cognitive, insight and functioning indices improved at the end of CACR intervention, as well as 3 and 6 month after the end of CACR program. No significant difference of cognitive, insight and functioning indices emerged between SDD and LDD during the 6-month follow-up period. Findings from this preliminary report revealed that CACR is an efficacious strategy to improve cognition, and consequently insight and functioning, in PSZ both in early-stage and chronic disorder.